Thermo Fisher Scientific SFPQ Recombinant Rabbit Monoclonal Antibody (ARC0788)
SFPQ 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity Chromatography 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50–1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0788 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 600–707 of human SFPQ (P23246) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849276 |
Product Specific Information
Immunogen sequence:
MGYMDPRERD MRMGGGGAMN MGDPYGSGGQ KFPPLGGGGG IGYEANPGVP PATMSGSMMG SDMRTERFGQ GGAGPVGGQG PRGMGPGTPA GYGRGREEYE GPNKKPRF
Target Information
SFPQ (also known as PSF) encodes a nuclear factor involved in RNA splicing and gene expression regulation. It likely forms a heteromer with NONO and participates in DNA pairing and repair processes.
Recent studies identified SFPQ as a downstream target of tau, showing nuclear depletion and cytoplasmic accumulation in neurons and astrocytes of Alzheimer’s disease (AD) brains. Reduced SFPQ levels may correlate with tau pathology, suggesting a key role in neurodegenerative diseases including AD.
SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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