Thermo Fisher Scientific SFPQ Recombinant Rabbit Monoclonal Antibody (ARC0788)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:200

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0788

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 600-707 of human SFPQ (P23246) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SFPQ,uniProtId:P23246-1,ncbiNodeId:9606,antigenRange:600-707,antigenLength:707,antigenImageFileName:MA5-35375_SFPQ_P23246-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35375_SFPQ_P23246-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849276

Product Specific Information

Immunogen sequence: MGYMDPRERD MRMGGGGAMN MGDPYGSGGQ KFPPLGGGGG IGYEANPGVP PATMSGSMMG SDMRTERFGQ GGAGPVGGQG PRGMGPGTPA GYGRGREEYE GPNKKPRF

Target Information

SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer`s disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.