Thermo Fisher Scientific Phospho-ASK1 (Ser966) Polyclonal Antibody
ASK1 단백질의 Ser966 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat에 반응합니다. 고순도 정제 및 안정적 PBS/glycerol buffer로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human MAP3K5 (Accession Q99683), corresponding to amino acid residues around phosphorylated Ser966 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816500 |
Product Specific Information
This antibody detects endogenous levels of ASK1 only when phosphorylated at Serine 966.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by extracellular stimuli such as cytokines, growth factors, and environmental stresses. ASK1 activates MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases. ASK1/MAPKKK5 interacts with TRAF family members and Daxx to mediate TNFR and Fas signaling pathways. Overexpression induces apoptosis, while inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-105027_ASK1_Q99683-1_Rabbit.svg, PA5-105027_ASK1_Q99683-1_Rabbit_PDP.jpeg)
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