Thermo Fisher Scientific Pierce Premium Grade TCEP-HCl, 1 g

Thermo Scientific™ Pierce™ Premium Grade TCEP-HCl

Thermo Scientific Pierce Premium Grade TCEP-HCl is the highest quality formulation of this disulfide reducing agent, specially characterized for applications where product integrity and risk minimization are paramount.

Features of Premium Grade TCEP-HCl

• TCEP: Thiol-free, odorless yet potent reducing agent for cleaving disulfide bonds
• High quality: Identity and purity confirmed by multiple tests, including quantitative NMR
• Product integrity: Enhanced level of testing and characterization compared to standard grade
• Lot retention: Ample supply of past lots retained to ensure future process testing
• Change management: Change Control Notification (CCN) service
• Consistent manufacture: Batch-specific manufacturing documentation review

Compared to the standard grade product, Premium Grade TCEP-HCl provides more clearly defined quality and product support through:

1. Increased analytical testing and product characterization
2. Greater batch-specific information and quality assurance review
3. Extensive lot sample retention
4. Change control notification

TCEP-HCl is pure, crystalline Tris(2-carboxyethyl)phosphine hydrochloride, a thiol-free compound highly effective at reducing protein and peptide disulfide bonds. It is odorless, stable, and selectively reduces even the most stable water-soluble alkyl disulfides over a wide pH range.

Advantages of TCEP-HCl over other reducing agents

• Odorless: Unlike DTT or BME, TCEP is odor-free, allowing convenient bench-top reductions
• Stable in air: Inherent stability eliminates the need for special precautions against oxidation
• Efficient: 5–50 mM TCEP effectively reduces peptide or protein disulfide bonds within minutes at room temperature
• Compatible: No need to remove reducing agent prior to most applications (e.g., His-tag purification, maleimide conjugations)

Related Products

• Pierce™ TCEP-HCl

Specifications