Thermo Fisher Scientific CADPS2 Polyclonal Antibody
Rabbit polyclonal antibody against human CADPS2, validated for WB and ELISA. Recognizes amino acids 1–80 of CADPS2. Suitable for research on synaptic vesicle priming and neuronal development. Supplied as liquid, unconjugated, 0.86 mg/mL, stored at -20°C.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–80 of human CADPS2 (NP_001009571.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.86 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854888 |
Product Specific Information
Immunogen sequence:
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS PSVLSEGRDE PQRQLDDEQE
Target Information
CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca²⁺-regulated exocytosis of secretory vesicles. CAPS-deficient neurons contain few fusion-competent synaptic vesicles, causing selective impairment of fast phasic transmitter release.
Like CAPS1, numerous isoforms of CAPS2 exist and show distinct expression patterns in the brain. For example, CAPS2b shows high expression in the developing cerebellum. One version of CAPS2 mRNA lacking exon 3 is detected in some autistic patients, suggesting involvement of CAPS2 in neuronal development.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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