Thermo Fisher Scientific CALHM1 Polyclonal Antibody
CALHM1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 랫트 시료에 반응합니다. Western blot, IHC, ELISA에 사용 가능하며, 알츠하이머 관련 연구에 적합합니다. 고순도 친화성 크로마토그래피 정제 및 안정적 액상 형태로 제공됩니다.
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- PA5109478
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Thermo Fisher Scientific CALHM1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 202–346 of human CALHM1 (NP_001001412.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854889 |
Product Specific Information
Immunogen sequence:
VRSVRPCFTQ AAFLKSKYWS HYIDIERKLF DETCTEHAKA FAKVCIQQFF EAMNHDLELG HTHGTLATAP ASAAAPTTPD GAEEEREKLR GITDQGTMNR LLTSWHKCKP PLRLGQEEPP LMGNGWAGGG PRPPRKEVAT YFSKV
Target Information
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by neuronal loss and senile plaques composed of aggregated amyloid-beta (Abeta) peptides. CALHM1 (Calcium Homeostasis Modulator 1) is a multipass transmembrane glycoprotein that regulates cytosolic Ca²⁺ concentration and Abeta levels. Some studies suggest CALHM1 may be associated with AD risk, while others report no correlation. CALHM1 may modulate the Ca²⁺-dependent proteolytic processing of APP through regulation of cytosolic Ca²⁺ levels.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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