Thermo Fisher Scientific CALU Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Calumenin,uniProtId:O43852-1,ncbiNodeId:9606,antigenRange:20-315,antigenLength:315,antigenImageFileName:PA5-109479_Calumenin_O43852-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109479_Calumenin_O43852-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.88 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854890

Product Specific Information

Immunogen sequence: KPTEKKDRVH HEPQLSDKVH NDAQSFDYDH DAFLGAEEAK TFDQLTPEES KERLGKIVSK IDGDKDGFVT VDELKDWIKF AQKRWIYEDV ERQWKGHDLN EDGLVSWEEY KNATYGYVLD DPDPDDGFNY KQMMVRDERR FKMADKDGDL IATKEEFTAF LHPEEYDYMK DIVVQETMED IDKNADGFID LEEYIGDMYS HDGNTDEPEW VKTEREQFVE FRDKNRDGKM DKEETKDWIL PSDYDHAEAE ARHLVYESDQ NKDGKLTKEE IVDKYDLFVG SQATDFGEAL VRHDEF

Target Information

Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.