Thermo Fisher Scientific ROCK1 Monoclonal Antibody (GT464)
ROCK1 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot에 최적화되어 있습니다. Human, Mouse, Rat 시료에 반응하며, 세포 분화 및 이동 관련 연구에 적합합니다. Protein G로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT464 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human ROCK1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735349 |
Product Specific Information
- Positive Control: 293T, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, PC-12 (30 µM cisplatin for 24 hr)
- Predicted Reactivity: Zebrafish (90%), Rabbit (98%), Chicken (96%), Rhesus Monkey (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration. The Rho/ROCK pathway is involved in the progression of various human cancers. ROCK1 acts as a Caspase-3 substrate and contributes to myosin light chain (MLC) activation through direct phosphorylation and inhibition of MLC phosphatase. During apoptosis, caspase-3 cleaves ROCK1, removing its inhibitory domain and resulting in constitutive kinase activity that induces membrane blebbing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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