Thermo Fisher Scientific Phospho-Androgen Receptor (Ser650) Polyclonal Antibody
인산화된 Androgen Receptor(Ser650)를 인식하는 Rabbit Polyclonal Antibody로 인간 및 랫트 시료에 반응합니다. IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 고순도(>95%)를 유지합니다.
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Thermo Fisher Scientific Phospho-Androgen Receptor (Ser650) Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 650 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553616 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 110 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT).
Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is crucial for male reproductive organ development and function, and also affects muscle, hair follicles, and brain.
Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility.
Mutations in the AR gene can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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