Thermo Fisher Scientific ALK Monoclonal Antibody (OTI8G7), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) is a member of the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often lead to the formation of the NPM-ALK fusion gene, which is oncogenic.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It is essential for neuronal development and function within the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.