Thermo Fisher Scientific ALK Monoclonal Antibody (OTI3H7), TrueMAB
Thermo Fisher Scientific의 ALK Monoclonal Antibody (OTI3H7)는 인간 ALK 단백질을 인식하는 Rat IgG2a 형 단일클론 항체입니다. Western blot에 최적화되어 있으며, 뇌 발달 및 종양 관련 연구에 유용합니다. Lyophilized 형태로 제공되며, -20°C에서 안정적으로 보관 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene have been identified in various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements often lead to the formation of NPM-ALK fusion genes, which are oncogenic.
ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK. It is essential for neuronal development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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