Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI5B3), TrueMAB
ABCB1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot과 IHC(Paraffin)에 사용 가능. 인간 시료 반응성. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 다약제 내성 연구 및 약물 수송 단백질 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell. Target family: P-Glycoprotein (ABCB1), UniProt ID: P08183-1, Antigen range: 995–1280 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily, involved in multidrug resistance. It acts as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and mediating resistance to anticancer drugs. Additionally, it functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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