Thermo Fisher Scientific PTEN Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is PC-3 cell lysate.
• PA5-20417 can be used with blocking peptide PEP-0534.

Target Information

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.
The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to that of dual specificity protein tyrosine phosphatases.
Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate.
It functions as a tumor suppressor by negatively regulating the AKT/PKB signaling pathway.
PTEN modulates the AKT-mTOR signaling pathway, influencing neuron positioning, dendritic development, and synapse formation during adult neurogenesis.
Additionally, PTEN may act as a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.