Thermo Fisher Scientific PTEN Polyclonal Antibody
PTEN 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 사용 가능. Human 및 Mouse 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 종양 억제 연구 및 AKT/mTOR 신호 경로 분석에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PTEN Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human PTEN. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156828 |
Product Specific Information
- A suggested positive control is PC-3 cell lysate.
- PA5-20417 can be used with blocking peptide PEP-0534.
Target Information
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.
The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to that of dual specificity protein tyrosine phosphatases.
Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate.
It functions as a tumor suppressor by negatively regulating the AKT/PKB signaling pathway.
PTEN modulates the AKT-mTOR signaling pathway, influencing neuron positioning, dendritic development, and synapse formation during adult neurogenesis.
Additionally, PTEN may act as a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.