Thermo Fisher Scientific PTEN Polyclonal Antibody
PTEN 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot, ICC/IF, IP 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 냉장 또는 -20°C 장기 보관 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| In vitro Assay (IV) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human PTEN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152102 |
Product Specific Information
A suggested positive control is P815 cell lysate.
PA5-20418 can be used with blocking peptide PEP-0535.
Target Information
PTEN was identified as a tumor suppressor frequently mutated in various cancers. The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases.
Unlike most tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates, negatively regulating intracellular levels of phosphatidylinositol-3,4,5-trisphosphate and the AKT/PKB signaling pathway.
PTEN modulates the AKT-mTOR signaling pathway, influencing neuron positioning, dendritic development, and synapse formation during adult neurogenesis. It may also negatively regulate insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form shows greater apoptotic potential, while the cytoplasmic nonubiquitinated form has reduced tumor suppressive ability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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