Thermo Fisher Scientific Phospho-TrkB (Tyr816) Polyclonal Antibody
Phospho-TrkB (Tyr816) 특이적 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC에 적합하며, 신경계 발달 및 유지 관련 연구에 활용됩니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적입니다.
- 카탈로그번호
- OST00221G-500UG
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | – |
| Immunohistochemistry (IHC) | 10–50 µg/mL | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat TrkB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in human and mouse.
- Specificity: TrkB.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family essential for the development and maintenance of the mammalian nervous system.
It serves as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation in brain synapses.
TrkB is a tyrosine kinase receptor involved in neuronal differentiation and maintenance. It is primarily expressed in central and peripheral nervous system tissues.
BDNF and NT-3 can induce rapid tyrosine phosphorylation of TrkB gp145, with BDNF eliciting a much stronger response than NT-3.
Signaling through TrkB activates the MAPK pathway, leading to cell differentiation.
Mutations in the TrkB gene have been linked to obesity and mood disorders. Alternative splice variants encode different isoforms of TrkB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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