Thermo Fisher Scientific Phospho-TrkB (Tyr816) Polyclonal Antibody
Phospho-TrkB (Tyr816) 인산화 부위를 인식하는 sheep polyclonal antibody로, Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 신경계 발달 및 BDNF 신호전달 연구용에 적합. 동결건조 상태로 제공되며, 재구성 후 4°C 또는 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 730–821 (including phospho Y816 site) of rat TrkB conjugated to a blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at –20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in human and mouse.
- Specificity: TrkB.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family central to the development and maintenance of the mammalian nervous system.
It is the receptor for brain-derived neurotrophic factor (BDNF), regulating both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation.
Mutations in the TrkB gene have been associated with obesity and mood disorders.
Alternate splice variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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