Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: View 3 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: TRPV6.

Target Information

Calcium-permeable channels such as TRPV6 participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger.
Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
This calcium-selective cation channel is involved in Ca²⁺ uptake in various tissues, including intestinal Ca²⁺ reabsorption.
The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation mechanisms include both rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent processes, which may be regulated by phosphorylation.
In vitro, the channel is slowly inhibited by Mg²⁺ in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties. TRPV5–TRPV6 heteromultimers exhibit voltage-dependent gating.
Interactions include TRPV5, S100A10, ANAX2–S100A10 heterotetramer, BSPRY, and calmodulin.
The interaction with S100A10 is required for trafficking to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• Immunogen image: OST00215W-100UL_TRPV6_Q9H1D0-1_Rabbit.svg
• PDP image: OST00215W-100UL_TRPV6_Q9H1D0-1_Rabbit_PDP.jpeg