Thermo Fisher Scientific CD1a Monoclonal Antibody (7A7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15830 targets CD1A in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of human CD1A expressed in E. coli.
MA5-15830 detects CD1A, which has a predicted molecular weight of approximately 37 kDa.

Target Information

CD1a is a non-polymorphic MHC Class I-related cell surface glycoprotein expressed in association with β2-microglobulin. It is found on cortical thymocytes, Langerhans cells, and interdigitating cells, as well as in some T-cell malignancies and histiocytosis X.
CD1a is structurally related to MHC proteins and forms heterodimers with β2-microglobulin. The CD1 family mediates presentation of lipid and glycolipid antigens of self or microbial origin to T cells.
The human genome contains five CD1 family genes (CD1a, b, c, d, e) organized in a cluster on chromosome 1. These family members differ in localization and lipid ligand specificity. CD1a localizes to the plasma membrane and early endocytic recycling vesicles. Alternatively spliced transcript variants have been observed, though their biological validity is undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.