Thermo Fisher Scientific Cortactin Monoclonal Antibody (4C6)
Human 및 Mouse 시료에서 Cortactin(CTTN)을 검출하는 Mouse IgG1 단클론 항체. Western blot, IHC, ELISA 등에 적합. 비결합형 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장. 세포 이동 및 액틴 구조 연구에 활용 가능.
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Thermo Fisher Scientific Cortactin Monoclonal Antibody (4C6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C6 |
| Immunogen | Purified recombinant fragment of human CTTN expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154788 |
Product Specific Information
MA5-15831 targets CTTN in indirect ELISA, IHC, and WB applications and shows reactivity with Human and Mouse samples.
The immunogen is a purified recombinant fragment of human CTTN expressed in E. coli.
MA5-15831 detects CTTN, which has a predicted molecular weight of approximately 80 kDa.
Target Information
Cortactin (CTTN) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape, and plays a role in lamellipodia formation and cell migration.
Cortactin localizes to peripheral actin-enriched structures, facilitating actin network formation. It has four major domains: N-terminal acidic (NTA), tandem repeats, proline-rich, and SH3 domains.
NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin promotes cell motility and invasion, playing a critical role in invadopodia formation and ECM degradation by cancer cells.
It is phosphorylated by Src family kinases at Y421, Y466, and Y482, and by Erk family kinases at S405 and S418.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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