Thermo Fisher Scientific Cortactin Monoclonal Antibody (4C6)

Thermo Fisher Scientific Cortactin Monoclonal Antibody (4C6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15831 targets CTTN in indirect ELISA, IHC, and WB applications and shows reactivity with Human and Mouse samples.
The immunogen is a purified recombinant fragment of human CTTN expressed in E. coli.
MA5-15831 detects CTTN, which has a predicted molecular weight of approximately 80 kDa.

Target Information

Cortactin (CTTN) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape, and plays a role in lamellipodia formation and cell migration.
Cortactin localizes to peripheral actin-enriched structures, facilitating actin network formation. It has four major domains: N-terminal acidic (NTA), tandem repeats, proline-rich, and SH3 domains.
NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin promotes cell motility and invasion, playing a critical role in invadopodia formation and ECM degradation by cancer cells.
It is phosphorylated by Src family kinases at Y421, Y466, and Y482, and by Erk family kinases at S405 and S418.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.