Thermo Fisher Scientific Phospho-Caspase 9 (Tyr153) Polyclonal Antibody
인간 Caspase 9의 Tyr153 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Western Blot과 Immunocytochemistry에 적합합니다. 액상 형태이며 1 mg/mL 농도로 제공되며, -20°C에서 보관합니다. 세포 사멸 연구 및 Caspase 경로 분석에 유용합니다.
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Thermo Fisher Scientific Phospho-Caspase 9 (Tyr153) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Caspase 9 around the phosphorylation site of Tyr153 (L-A-YP-I-L) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555037 |
Target Information
Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 containing a CARD domain. Caspases are cysteine proteases expressed as inactive precursors that mediate apoptosis through proteolysis of specific substrates.
Caspase 9 functions as a heterotetramer, existing in the cytosol and translocating to mitochondria upon activation. It plays a central role in the caspase activation cascade responsible for apoptosis execution, activating Caspase 3 and Caspase 6. Caspase 9 also promotes DNA damage-induced apoptosis in an ABL1/c-Abl-dependent manner and cleaves poly(ADP-ribose) polymerase (PARP).
It is expressed in various human tissues, and its dysfunction is associated with abnormal brain development, cancer progression, and neurodegenerative diseases such as Alzheimer’s disease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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