Thermo Fisher Scientific Phospho-Caspase 3 (Ser150) Polyclonal Antibody
인간 Caspase 3의 Ser150 인산화 부위에 특이적인 Rabbit Polyclonal 항체로, Western Blot과 IHC(P) 분석에 적합합니다. 액상형, 1 mg/mL 농도이며 -20°C에서 보관합니다. 세포 사멸 연구 및 신경퇴행성 질환 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Caspase 3 around the phosphorylation site of Ser150 (C-R-SP-L-T) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555039 |
Target Information
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits that dimerize to form the active enzyme.
Caspase 3 cleaves and activates caspases 6, 7, and 9, and is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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