Thermo Fisher Scientific ICOSLG Monoclonal Antibody (2D12)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2D12

Immunogen

ICOSLG (AAH64637, 20 a.a. approximately 302 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD275 (B7-H2),uniProtId:O75144-1,ncbiNodeId:9606,antigenRange:20-302,antigenLength:302,antigenImageFileName:H00023308-M04_CD275_B7-H2_O75144-1_House_mouse.svg,antigenImageFileNamePDP:H00023308-M04_CD275_B7-H2_O75144-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: TQEKEVRAMV GSDVELSCAC PEGSRFDLND VYVYWQTSES KTVVTYHIPQ NSSLENVDSR YRNRALMSPA GMLRGDFSLR LFNVTPQDEQ KFHCLVLSQS LGFQEVLSVE VTLHVAANFS VPVVSAPHSP SQDELTFTCT SINGYPRPNV YWINKTDNSL LDQALQNDTV FLNMRGLYDV VSVLRIARTP SVNIGCCIEN VLLQQNLTVG SQTGNDIGER DKITENPVST GEKNAATWSI LAVLCLLVVV AVAIGWVCRD RCLQHSYAGA WAVSPETELT GHV

Target Information

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.