Thermo Fisher Scientific FBXW11 Monoclonal Antibody (2E7)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein Sequence:

MEPDSVIEDK TIELMNTSVM EDQNEDESPK KNTLWQISNG TSSVIVSRKR PSEGNYQKEK DLCIKYFDQW SESDQVEFVE HLISRMCHYQ HGHINSYLKP MLQRDFITAL PEQGLDHIAE NILSYLDARS LCAAELVCKE WQRVISEGML WKKLIERMVR TDPLWKGLSE RRGWDQYLFK NRPTDGPPNS FYRSLYPKII QDIETIESNW RCGRHNLQRI QCRSENSKGV YCLQYDDEKI ISGLRDNSIK IWDKTSLECL KVLTGHTGSV LCLQYDERVI VTGSSDSTVR VWDVNTGEVL NTLIHHNEAV LHLRFSNGLM VTCSKDRSIA VWDMASATDI TLRRVLVGHR AAVNVVDFDD KYIVSASGDR TIKVWSTSTC EFVRTLNGHK RGIACLQYRD RLVVSGSSDN TIRLWDIECG ACLRVLEGHE ELVRCIRFDN KRIVSGAYDG KIKVWDLQAA LDPRAPASTL CLRTLVEHSG RVFRLQFDEF QIISSSHDDT ILIWDFLNVP PSAQNETRSP SRTYTYISR

Target Information

This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif.
F-box proteins are subunits of the ubiquitin protein ligase complex (SCF complex), functioning in phosphorylation-dependent ubiquitination.

F-box proteins are classified into:

• Fbws: containing WD-40 domains
• Fbls: containing leucine-rich repeats
• Fbxs: containing other protein interaction modules or no recognizable motifs

The FBXW11 gene belongs to the Fbws class and contains multiple WD40 repeats. It comprises at least 14 exons, and alternative splicing produces 3 transcript variants differing by the presence or absence of two alternate exons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.