Thermo Fisher Scientific Cofilin Polyclonal Antibody
Cofilin 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Flow cytometry에 적합. Human 및 Mouse에 반응하며, 단백질 A 및 항원 친화 크로마토그래피로 정제됨. 세포 골격 조절 연구용으로 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 70–98 amino acids from the central region of human CFL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542128 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, porcine, non-human primate, rat, and Xenopus based on sequence homology.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics and is important for normal mitosis and cytokinesis. Cofilin plays a key role in cell morphology, cytoskeletal organization, and neural tube morphogenesis. It is also required for the regulation of atypical chemokine receptor ACKR2 trafficking, enhancing chemokine uptake and degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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