Thermo Fisher Scientific HSC70 Polyclonal Antibody
HSC70 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat에 반응합니다. 고순도 정제 및 안정적 액상 형태로 제공됩니다.
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Thermo Fisher Scientific HSC70 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between 82–110 amino acids from the N-terminal region of human HSPA8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542124 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, hamster, mouse, and rat based on sequence homology.
Target Information
The HSP70 family consists of highly conserved proteins induced by various biological stresses, including heat stress, across organisms.
Human HSP70 family members include:
- HSP70: Strongly inducible and constitutively expressed in primate cells
- HSP72: 72 kDa protein induced under stress conditions
- HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73): Constitutively expressed, slightly heat-inducible, involved in uncoating clathrin-coated vesicles and cytoskeletal rearrangements
- GRP78 (BiP): 78 kDa glucose-regulated protein localized in the endoplasmic reticulum
- p75 (HSP75): 75 kDa mitochondrial protein
HSC70 promotes uncoating of clathrin-coated vesicles, binds cytoskeletal components, stimulates lysosomal degradation of intracellular proteins, and modulates folding of mitochondrial precursor proteins in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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