Thermo Fisher Scientific APOBR Monoclonal Antibody (OTI1B5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Macrophage receptor that binds to apolipoprotein B48 (APOB) of dietary triglyceride-rich lipoproteins (TRL) or similar domains in hypertriglyceridemic very low-density lipoprotein (HTG-VLDL).
Functions include:

• Binding and internalizing TRL outside macrophage context
• Providing essential lipids to reticuloendothelial cells
• Possible involvement in foam cell formation with elevated TRL and remnant lipoprotein (RLP)
• Mediates rapid, high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized VLDL devoid of APOE in vitro in macrophages

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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