Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI6D10), TrueMAB
Human NAB2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 핵 내 전사 조절 연구 및 NGFI-A 관련 단백질 연구에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins).
NAB proteins (NAB1 and NAB2) act as corepressors of EGF-1/NGFI-A. Both contain an N-terminal NAB conserved domain 1 (NCD1) for NGFI-A binding and a C-terminal NCD2 domain responsible for repressor function.
NAB2 is mainly localized in the nucleus and may be involved in downregulating NGFI-A activity, as well as in cell division, differentiation, and apoptosis regulation.
NAB2 has a predicted molecular mass of 56 kDa and is located on chromosome 12q13.3–14.1, a region associated with rearrangements in various solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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