Thermo Fisher Scientific TNFAIP3 Polyclonal Antibody
TNFAIP3(A20) 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 단백질에 반응합니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Gly267 of human A20/TNFAIP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977397 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It has been identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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