Thermo Fisher Scientific GFAP Monoclonal Antibody (6F2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-06701 detects GFAP in human samples.
It has been successfully used in Western blotting and immunohistochemistry procedures.
By Western blot, MA1-06701 detects a ~55 kDa protein representing GFAP.
The immunogen is glial fibrillary acidic protein from human brain.

Target Information

GFAP (Glial Fibrillary Acidic Protein) is a member of the class III intermediate filament protein family.
It is specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. Neural stem cells also strongly express GFAP.

Antibodies to GFAP are useful as markers of astrocytic cells. Many brain tumors derived from astrocytic cells also express GFAP.
GFAP is additionally found in the lens epithelium, Kupffer cells of the liver, some salivary tumor cells, and occasionally in erythrocytes.

GFAP serves as a marker to distinguish astrocytes from other glial cells during development.
Mutations in the GFAP gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.