Thermo Fisher Scientific PKP3 Monoclonal Antibody (23E3/4)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:200

-

Immunohistochemistry (Frozen) (IHC (F))

1:25-1:200

-

Immunocytochemistry (ICC/IF)

1:25-1:200

-

Immunoprecipitation (IP)

Assay-dependent

-

Miscellaneous PubMed (Misc)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

23E3/4

Immunogen

Synthetic peptide corresponding to residues F(570) T P Q S R R L R E L P L A A D A L T F(589) of human plakophilin-3. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PKP3,uniProtId:Q9Y446-1,ncbiNodeId:9606,antigenRange:570-589,antigenLength:797,antigenImageFileName:MA1-06511_PKP3_Q9Y446-1_House_mouse.svg,antigenImageFileNamePDP:MA1-06511_PKP3_Q9Y446-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2283813

Product Specific Information

MA1-06511 detects plakophilin-3 in human, mouse, canine cells.

MA1-06511 has sucessfully been used in Western blotting, immunoprecipitation, immunocytochemistry and immunohistochemistry procedures. By Western blot it detects a ~87 kDa band representing Plakophilin-3.

The MA1-06511 immunogen is a synthetic peptide corresponding to residues F(570) T P Q S R R L R E L P L A A D A L T F(589) of human plakophilin-3.

Target Information

Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of ~87 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.