Thermo Fisher Scientific MIP-3 beta Recombinant Rabbit Monoclonal Antibody (3A12)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology.
CCL19 and CCL21 are expressed mainly by stromal cells in T cell-rich zones of lymph nodes and are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs.
They also play roles in T cell priming, activation, and recruitment of lymphocytes to inflamed tissue. Both signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells.
Although both exhibit the same affinity for CCR7, only CCL19 binding results in desensitization and internalization of the receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.