Thermo Fisher Scientific Phospho-DNA-PK (Ser2056) Recombinant Rabbit Monoclonal Antibody (4A4)
Phospho-DNA-PK (Ser2056)을 인식하는 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. ICC/IF 및 ELISA에 사용 가능하며, 고순도의 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로 적합합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:20–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4A4 |
| Immunogen | A synthesized peptide derived from human Phospho-PRKDC (S2056) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092652 |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting transcriptional pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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