Thermo Fisher Scientific CD267 (TACI) Monoclonal Antibody (11H3), Biotin, eBioscience

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• Functional Grade
• PE
• Request custom conjugation

Product Specific Information

The 11H3 antibody reacts with human TACI (tumor necrosis factor receptor 13B). TACI, like BCMA, binds BAFF and APRIL, regulating humoral immune responses and activating NF-κB and c-Jun N-terminal kinase. It is involved in B cell-associated autoimmune diseases. TACI mRNA and protein are predominantly expressed in B cells and correlate with BLyS binding in B-cell lines. TACI interacts with APRIL with nanomolar affinity but 11H3 does not block BAFF/BLyS binding to TACI.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of normal human blood cells. Recommended ≤0.5 µg per test (defined as the amount that will stain a 100 µL cell sample). Optimal titration is recommended for best performance.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Members of the TNF superfamily regulate immune responses and induce apoptosis. BAFF (also known as BLyS/TALL-1/THANK/zTNF4) and APRIL (TALL-2) are two such members. BAFF acts as a B cell activator inducing proliferation and immunoglobulin secretion, while APRIL regulates both immunological and non-immunological cell growth. Three receptors—BCMA, TACI, and BAFF-R—bind BAFF and APRIL. TACI and its ligands play key roles in humoral immune regulation and B cell-related autoimmune disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.