Thermo Fisher Scientific IL-33R (ST2) Monoclonal Antibody (RMST2-2), Biotin, eBioscience
IL-33R(ST2) 단백질을 인식하는 Biotin 결합 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. 마우스 시료에 적용 가능하며, 0.5 µg/test로 사용됩니다. IL-33/ST2 신호 경로 연구 및 면역세포 분석에 유용합니다.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-33R (ST2) Monoclonal Antibody (RMST2-2), Biotin, eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 7 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RMST2-2 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572810 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Brilliant UV 395
- Brilliant UV 615
- Brilliant UV 737
- Brilliant Violet 421
- eFluor 450
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
Description:
The RMST2-2 monoclonal antibody reacts with ST2 (IL-33 receptor, IL-33R, or interleukin 1 receptor-like 1), a member of the IL-1 receptor family. The membrane-bound form has three extracellular immunoglobulin domains and an intracellular toll-interleukin-1 receptor domain. ST2 dimerizes with IL-1R accessory protein in a ligand-dependent manner, and IL-33/ST2 interaction induces TH2 cytokine production. The soluble isoform acts as a decoy receptor, blocking IL-33/ST2 signaling.
ST2 is expressed by TH2 lymphocytes, mast cells, eosinophils, basophils, innate lymphocytes, smooth muscle, and endothelial cells, and is involved in host defense, allergy, and inflammation. The IL-33/ST2 interaction has been shown to be atheroprotective.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse bone marrow-derived mast cells. Recommended ≤0.5 µg per test (in 100 µL final volume, cell number 10⁵–10⁸ cells/test). Antibody should be titrated for optimal performance.
Target Information
IL-33R (ST2):
Receptor for IL-33 and member of the IL-1 receptor family. Its extracellular domain contains three Ig-like domains that interact with IL-1RAcP and IL-33. IL-33 ligation activates MyD88, IRAK1, IRAK4, and TRAF6, leading to NF-κB and MAPK pathway activation and release of cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two main isoforms exist: ST2L (membrane-bound) and ST2S (soluble). The soluble form acts as a decoy receptor, dampening IL-33 signaling. Expressed mainly by mast cells, basophils, eosinophils, and in mice also by ILC2 and Th2 cells. IL-33R signaling is implicated in allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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