Thermo Fisher Scientific Human FLT3 [D835Y], His Tag Recombinant Protein

Thermo Fisher Scientific Human FLT3 [D835Y], His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Publications

• [References not provided]

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, prepare aliquots to reduce freeze/thaw cycles (do not prepare aliquots below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.
• Protein Form: Cytoplasmic

Target Information

FLT3 is a tyrosine protein kinase belonging to the growth factor receptor tyrosine kinase family. Activation occurs via binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, inducing homodimer formation and autophosphorylation in the plasma membrane. The activated receptor phosphorylates and activates multiple cytoplasmic effector molecules, playing roles in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Constitutive activation mutations are associated with acute myeloid leukemia and acute lymphoblastic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.