Thermo Fisher Scientific Human MET [M1250T], His Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use in original packaging until exhausted.
For larger sizes, aliquot preparation may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
Never store a kinase diluted.
Properly stored at -80°C, product stability is guaranteed for 6 months from date of purchase.

Protein Form: Cytoplasmic

Target Information

MET (cMET) is a receptor-like tyrosine kinase implicated in multiple human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, initiating signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET functions in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling).
Dysregulation of MET is associated with cancers including gastric, renal, and breast, making it a key target for cancer therapeutics and diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.