![Thermo Fisher Scientific Human MET [M1250T], His Tag Recombinant Protein](https://images.cacheby.com/product-images-normalized/shared/857c0ec6cfd00134.png?s=800x800&t=contain&q=82&f=webp)
Thermo Fisher Scientific Human MET [M1250T], His Tag Recombinant Protein
Human MET (M1250T) His-tag recombinant protein for kinase assays and signaling studies. Expressed in insect cells, purified liquid form with 53.7 kDa molecular weight. Stable at -80°C; used for cancer research and receptor tyrosine kinase analysis.
- 카테고리
- Protein
- 판매단위
- pk
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Applications
- Kinase Assay (KA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 956–1390; M1250T |
| Tag | His-tag |
| Molecular Weight | 53.7 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris-HCl (pH 7.5), 50% glycerol, 0.02% Triton X-100, 150 mM NaCl, 0.5 mM EDTA, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use in original packaging until exhausted.
For larger sizes, aliquot preparation may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
Never store a kinase diluted.
Properly stored at -80°C, product stability is guaranteed for 6 months from date of purchase.
Protein Form: Cytoplasmic
Target Information
MET (cMET) is a receptor-like tyrosine kinase implicated in multiple human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, initiating signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET functions in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling).
Dysregulation of MET is associated with cancers including gastric, renal, and breast, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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