Thermo Fisher Scientific CCDC134 Recombinant Rabbit Monoclonal Antibody (026)
인간 CCDC134 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot 및 immunoprecipitation에 적합. 높은 특이성과 민감도, 로트 간 일관성, 보존제 무첨가. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 026 |
| Immunogen | Recombinant Human CCDC134 protein (Met1–Leu229) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785016 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin–free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human CCDC134.
Target Information
The coiled-coil domain is a common protein motif involved in protein oligomerization, found in transcription factors and intermediate filaments.
CCDC134 is a secretory protein that inhibits the transcriptional activity of Elk1. Overexpression of CCDC134 inhibits phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while siRNA against CCDC134 activates Elk1 transcriptional activity and phosphorylation of Erk and JNK/SAPK.
This suggests a potential inhibitory role of CCDC134 in MAPK-mediated Elk1 transcription.
CCDC134 is widely expressed in normal adult tissues, tumors, and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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