Thermo Fisher Scientific TSC2 Monoclonal Antibody (T.309.0)
TSC2 단백질을 인식하는 Rabbit monoclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.309.0 |
| Immunogen | Synthetic peptide from the amino terminus of human tuberin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 270 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 50% glycerol, 0.15M NaCl, 100 µg/mL BSA |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10987349 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is a tumor suppressor protein that may function in vesicular transport and regulation of cell growth arrest, as well as transcription mediated by steroid receptors.
TSC2 forms a cytosolic complex with hamartin (TSC1), potentially acting as a chaperone. Phosphorylation at Ser 939 and Thr 1462 regulates its interaction with hamartin, which is influenced by growth factors via the PI3K/Akt pathway.
TSC2 stimulates the intrinsic GTPase activity of RAP1A and RAB5, suggesting a role in growth regulation. Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and angiomyolipoma.
Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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