Thermo Fisher Scientific p130 Polyclonal Antibody
Thermo Fisher Scientific의 p130 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 Rb2 p130 단백질을 검출합니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, Protein A로 정제된 고품질 항체입니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:200 | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | Assay-dependent | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of human Rb2 p130 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2175589 |
Product Specific Information
PA1-26037 detects Rb2 p130 from human, mouse, and rat samples.
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure, particularly constitutive heterochromatin, through stabilization of histone methylation.
RBL2 recruits histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression and control of histone H4 Lys20 trimethylation. It likely acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters and serves as a potent inhibitor of E2F-mediated trans-activation, associating preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA1-26037_p130_Q08999-1_Rabbit.svg, PA1-26037_p130_Q08999-1_Rabbit_PDP.jpeg)
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