Thermo Fisher Scientific Biliverdin Reductase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–10 µg/mL

Product Specifications

Product Specific Information

PA1-26089 detects Biliverdin Reductase from human, mouse, rat, hamster, and porcine samples.

Target Information

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among enzymes for being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as electron donors.
There are two isoforms:

• Biliverdin-IX alpha-reductase (BLVRA): Major component of human adult liver
• Biliverdin-IX beta-reductase (BLVRB): Found predominantly in fetal liver

The product of BLVR, bilirubin, acts as a biological antioxidant but can also be neurotoxic and cause kernicterus. In addition to its antioxidant properties, bilirubin inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.