Thermo Fisher Scientific Biliverdin Reductase Polyclonal Antibody
Rabbit polyclonal antibody recognizing Biliverdin Reductase across multiple species. Suitable for WB and IHC applications. Unconjugated, liquid form with 1 mg/mL concentration. For research use only; not for diagnostic procedures.
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- PA126089
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified, full length, native rat protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_779417 |
Product Specific Information
PA1-26089 detects Biliverdin Reductase from human, mouse, rat, hamster, and porcine samples.
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among enzymes for being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as electron donors.
There are two isoforms:
- Biliverdin-IX alpha-reductase (BLVRA): Major component of human adult liver
- Biliverdin-IX beta-reductase (BLVRB): Found predominantly in fetal liver
The product of BLVR, bilirubin, acts as a biological antioxidant but can also be neurotoxic and cause kernicterus. In addition to its antioxidant properties, bilirubin inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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