Thermo Fisher Scientific CD85j (ILT2) Monoclonal Antibody (HP-F1), FITC, eBioscience
CD85j(ILT2, LILRB1, LIR1)을 인식하는 FITC 결합 마우스 단클론 항체로, 인간 세포의 유세포분석(Flow Cytometry)에 적합합니다. NK, T, B세포 등에서 발현되는 CD85j 검출에 사용되며, 488 nm 레이저로 여기됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HP-F1 |
| Conjugate | FITC |
| Excitation/Emission Max | 498/517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2815037 |
Available Formats
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 737
- eFluor 450
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 700
- NovaFluor Red 725
- NovaFluor Yellow 570
- NovaFluor Yellow 590
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
Description:
Monoclonal antibody HP-F1 recognizes CD85j, also known as ILT2, LILRB1, and LIR1. CD85j is a transmembrane glycoprotein with four ITIMs that signal through SHP-1. It is expressed on myeloid cells (monocytes, dendritic cells) and subsets of NK, T, and B cells. Expression correlates with leukemias (ALL, CLL) and plays roles in viral infections such as HIV, Epstein-Barr, and CMV. Ligands include MHC Class I molecules (HLA-G, A, F, B27, E, F).
HP-F1 has been shown to reduce CD16-dependent cytolytic activity of NK cells.
Applications Reported:
Flow cytometric analysis.
Applications Tested:
Pre-diluted and tested by flow cytometry of normal human peripheral blood cells. Use at 5 µL (0.25 µg) per test in 100 µL final volume (10⁵–10⁸ cells/test).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Target Information
This gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family located on chromosome 19q13.4. The encoded protein has extracellular Ig domains, a transmembrane domain, and cytoplasmic ITIMs. It binds MHC class I molecules on antigen-presenting cells and transduces inhibitory signals to regulate immune responses, inflammation, and cytotoxicity. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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