Thermo Fisher Scientific CD85j (ILT2) Monoclonal Antibody (HP-F1), FITC, eBioscience

Applications and Tested Dilution

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Product Specifications

Available Formats

• Alexa Fluor 488
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Brilliant UV 737
• eFluor 450
• Functional Grade
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 700
• NovaFluor Red 725
• NovaFluor Yellow 570
• NovaFluor Yellow 590
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Request custom conjugation

Product Specific Information

Description:
Monoclonal antibody HP-F1 recognizes CD85j, also known as ILT2, LILRB1, and LIR1. CD85j is a transmembrane glycoprotein with four ITIMs that signal through SHP-1. It is expressed on myeloid cells (monocytes, dendritic cells) and subsets of NK, T, and B cells. Expression correlates with leukemias (ALL, CLL) and plays roles in viral infections such as HIV, Epstein-Barr, and CMV. Ligands include MHC Class I molecules (HLA-G, A, F, B27, E, F).

HP-F1 has been shown to reduce CD16-dependent cytolytic activity of NK cells.

Applications Reported:
Flow cytometric analysis.

Applications Tested:
Pre-diluted and tested by flow cytometry of normal human peripheral blood cells. Use at 5 µL (0.25 µg) per test in 100 µL final volume (10⁵–10⁸ cells/test).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Target Information

This gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family located on chromosome 19q13.4. The encoded protein has extracellular Ig domains, a transmembrane domain, and cytoplasmic ITIMs. It binds MHC class I molecules on antigen-presenting cells and transduces inhibitory signals to regulate immune responses, inflammation, and cytotoxicity. Multiple transcript variants exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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