Thermo Fisher Scientific HAS1 Monoclonal Antibody (5C9D6)
Western blot 및 유세포분석(Flow Cytometry)에 적합한 HAS1 단일클론 항체. 인간 및 생쥐 시료에 반응하며, Protein G로 정제된 1 mg/mL 액상 제품. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C9D6 |
| Immunogen | Purified recombinant fragment of human HAS1 (aa 74–399) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898446 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide found in the extracellular matrix of various organisms, from bacteria to mammals. It consists of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. HA is synthesized by membrane-bound synthase and extruded into the extracellular space, where it functions in space filling, joint lubrication, and as a scaffold for cell migration during wound healing and tissue repair.
Altered serum HA levels are associated with inflammatory and degenerative joint diseases such as rheumatoid arthritis. The interaction between HA and the leukocyte receptor CD44 plays a critical role in leukocyte homing, and overexpression of HA receptors correlates with tumor metastasis.
HAS1 is part of the vertebrate gene family encoding hyaluronan synthases, showing significant homology to the hasA gene product of Streptococcus pyogenes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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