Thermo Fisher Scientific FPR1 Polyclonal Antibody
인간 FPR1 단백질을 인식하는 Rabbit Polyclonal 항체로 면역조직화학(IHC) 적용 가능. 고순도 항원 친화 크로마토그래피 정제. 액상 형태, 1 mg/mL 농도. 연구용으로만 사용, 장기 보관 시 -20°C 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 2nd extracellular domain of human FPR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550915 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Chimpanzee, Gorilla (94%)
- Orangutan (88%)
- Gibbon (81%)
Target Information
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils, and monocytes.
It is a seven-transmembrane, pertussis toxin-sensitive GPCR that binds formylated peptides generated by bacteria, leading to leukocyte trafficking to sites of inflammation.
Ligand binding to FPR activates multiple effectors including phospholipase C, resulting in calcium mobilization and PKC activation.
FPR signaling also influences actin cytoskeleton polarization, integrin activation, cell migration, phagocytosis, degranulation, and release of reactive oxygen intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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