Thermo Fisher Scientific FPR3 Polyclonal Antibody
Thermo Fisher Scientific의 FPR3 Polyclonal Antibody는 인간 및 비인간 영장류 반응성을 가진 토끼 IgG 항체입니다. 면역조직화학(IHC)용으로 최적화되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 염증 및 신경질환 연구에 적합한 고품질 연구용 항체입니다.
- 카탈로그번호
- PA533540
- 판매단위
- pk
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Thermo Fisher Scientific FPR3 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 2nd transmembrane domain of human FPR3 / FPRH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550920 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%)
Gibbon (94%)
Target Information
The N-formyl peptide receptor (FPR) family is comprised of three members: FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2), and FPR like-2 (FPRL2). These are chemotactic G protein-coupled receptors with seven transmembrane domains, found on phagocytic leukocytes such as neutrophils and monocytes.
Each receptor has specific residues determining ligand specificity. FPR3 binds multiple ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide, and beta amyloid (42 amino acid form).
Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils, playing a role in inflammatory and host defense responses.
FPR3 may mediate inflammation in prion and Alzheimer’s diseases, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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