Thermo Fisher Scientific FPR1 Polyclonal Antibody
FPR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 비인간 영장류 시료에 반응합니다. IHC(P)에서 1–2 µg/mL 농도로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.1% sodium azide 포함, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 3rd extracellular domain of human FPR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550914 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Monkey (100%), Gorilla (94%), Orangutan (88%).
Target Information
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils, and monocytes.
It is a seven-transmembrane pertussis toxin-sensitive GPCR that binds to formylated peptides generated by bacteria, resulting in leukocyte trafficking to sites of inflammation.
Ligand binding to FPR activates multiple effectors including phospholipase C, leading to calcium mobilization and PKC activation.
Other implications of FPR signaling include polarization of the actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation, and release of reactive oxygen intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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