Thermo Fisher Scientific Roquin Polyclonal Antibody
Roquin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 1 mg/mL 농도의 액상 제품. 4°C에서 보관, 연구용 전용.
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Thermo Fisher Scientific Roquin Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:5,000
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 500 and 550 of Human Ring Finger and CCCH-type finder domains 1 (RC3H1, UniProt ID: Q5TC82-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The ring finger protein RC3H1 (Roquin) is a highly conserved member of the RING-type ubiquitin ligase protein family.
A mutation (M199R) in Roquin leads to excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, which show increased IL-21 production and high titers of autoantibodies.
Complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity, suggesting that the mutant form is more disruptive to the immune system than its absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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