Thermo Fisher Scientific Roquin Polyclonal Antibody
Roquin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP에 적합. Human과 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체이며 4°C 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 500 and 550 of Human Ring Finger and CCCH-type finder domains 1 (RC3H1, UniProt ID: Q5TC82-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING-type ubiquitin ligase protein family. The M199R mutation leads to excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, characterized by high IL-21 levels and autoantibody titers. Complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity, indicating that the mutant form is more disruptive than its absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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