Thermo Fisher Scientific PCBP1 Recombinant Rabbit Monoclonal Antibody (7Y8C5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LRLVVPATQC GSLIGKGGCK IKEIRESTGA QVQVAGDMLP NSTERAITIA GVPQSVTECV KQICLVMLET LSQSPQGRVM TIPYQPMPAS SPVICAGGQD R

Target Information

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. Along with PCBP-2 and hnRNPK, it corresponds to major cellular polydomains involved in RNA binding. This protein, together with PCBP-2, also functions as a translational coactivator of poliovirus RNA through sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. Additionally, it may play a role in forming a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.