Thermo Fisher Scientific IRE1 alpha Monoclonal Antibody (9F2)
Human IRE1 alpha 단백질을 인식하는 mouse monoclonal antibody로, Western blot, IHC, ELISA에 적합합니다. ER 스트레스 신호전달 연구에 활용 가능하며, 비결합형 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9F2 |
| Immunogen | Purified recombinant fragment of human ERN1 (aa 282–433) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10981082 |
Product Specific Information
MA5-15617 targets ERN1 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human ERN1 (aa 282–433) expressed in E. coli.
MA5-15617 detects ERN1, which has a predicted molecular weight of approximately 109 kDa.
Target Information
ERN1 (Endoplasmic Reticulum to Nucleus Signaling 1), also known as IRE1 alpha, is a serine/threonine kinase and endoribonuclease involved in the unfolded protein response (UPR) pathway.
It acts as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and initiates signaling to the nucleus by splicing XBP1 mRNA, converting it into a potent transcriptional activator.
ERN1 is essential for embryonic viability and cellular response to ER stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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