Thermo Fisher Scientific TAB1 Polyclonal Antibody
Rabbit Polyclonal TAB1 항체로, Western blot 및 Immunoprecipitation에 적합합니다. Human TAB1(aa 485-504) 부위를 면역원으로 사용하였으며, 1 mg/mL 농도의 액상 형태입니다. 4°C 보관, Wet ice 배송, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 485 and 504 of Human TAK1-binding protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein functions as a mediator between TGF beta receptors and TAK1. It can also interact with and activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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