Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), PE, eBioscience

Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 14 publications

Product Specifications

Additional Formats

• Alexa Fluor 647
• Alexa Fluor 660
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Brilliant UV 395 / 563 / 661 / 737 / 805
• Brilliant Violet 421 / 480 / 605 / 650 / 711 / 786
• eFluor 450 / 506
• FITC
• NovaFluor Blue 510 / Blue 660-120S / Red 700 / Yellow 590 / Yellow 610 / Yellow 700 / Yellow 730
• PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436 / 600 / 645 / 702 / 780
• Request custom conjugation

Product Specific Information

This 3DS223H monoclonal antibody recognizes human CD223, also known as Lymphocyte Activation Gene 3 (LAG-3). LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily with homology to CD4. It binds to MHC class II with higher affinity than CD4 and negatively regulates T cell activation and homeostatic proliferation.

Surface expression of LAG-3 occurs on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells express LAG-3 at higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b identifies human and mouse Type 1 regulatory T cells (Tr1 cells).

• Recognizes formaldehyde-fixed epitope
• Reported for flow cytometric analysis
• Tested on stimulated normal human peripheral blood cells
• Recommended use: 5 µL (0.06 µg) per test (100 µL final volume)
• Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. It binds MHC class II with high affinity and plays a role in negative regulation of T cell activation and homeostatic proliferation. Expressed on activated T cells, regulatory T cells, and NK cells. CD8+ T cells typically express higher levels than CD4+ T cells. Coexpression with CD49b identifies Tr1 cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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